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Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups
Version 2 2023-06-12, 09:40
Version 1 2023-06-09, 22:44
journal contribution
posted on 2023-06-12, 09:40 authored by Tewodros Gebresilase, Chris Finan, Daniel Suveges, Tesfaye Sisay Tessema, Abraham Aseffa, Gail DaveyGail Davey, Hatzikotoulas Konstantinos, Eleftheria Zeggini, Melanie NewportMelanie Newport, Fasil Tekola-AyelePodoconiosis, a debilitating lymphoedema of the leg, results from barefoot exposure to volcanic clay soil in genetically susceptible individuals. A previous genome-wide association study (GWAS) conducted in the Wolaita ethnic group from Ethiopia showed association between single nucleotide polymorphisms (SNPs) in the HLA class II region and podoconiosis. We aimed to conduct a second GWAS in a new sample (N?=?1892) collected from the Wolaita and two other Ethiopian populations, the Amhara and the Oromo, also affected by podoconiosis. Fourteen SNPs in the HLA class II region showed significant genome-wide association (P?
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- Published
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- Published version
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NatureISSN
0028-0836Publisher
Nature ResearchExternal DOI
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11Page range
1-11Article number
a3285Department affiliated with
- Global Health and Infection Publications
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- Yes
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- Yes
Legacy Posted Date
2021-01-13First Open Access (FOA) Date
2021-02-11First Compliant Deposit (FCD) Date
2021-01-13Usage metrics
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