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Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups

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Version 1 2023-06-09, 22:44
journal contribution
posted on 2023-06-12, 09:40 authored by Tewodros Gebresilase, Chris Finan, Daniel Suveges, Tesfaye Sisay Tessema, Abraham Aseffa, Gail DaveyGail Davey, Hatzikotoulas Konstantinos, Eleftheria Zeggini, Melanie NewportMelanie Newport, Fasil Tekola-Ayele
Podoconiosis, a debilitating lymphoedema of the leg, results from barefoot exposure to volcanic clay soil in genetically susceptible individuals. A previous genome-wide association study (GWAS) conducted in the Wolaita ethnic group from Ethiopia showed association between single nucleotide polymorphisms (SNPs) in the HLA class II region and podoconiosis. We aimed to conduct a second GWAS in a new sample (N?=?1892) collected from the Wolaita and two other Ethiopian populations, the Amhara and the Oromo, also affected by podoconiosis. Fourteen SNPs in the HLA class II region showed significant genome-wide association (P?

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Publication status

  • Published

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  • Published version

Journal

Nature

ISSN

0028-0836

Publisher

Nature Research

Volume

11

Page range

1-11

Article number

a3285

Department affiliated with

  • Global Health and Infection Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2021-01-13

First Open Access (FOA) Date

2021-02-11

First Compliant Deposit (FCD) Date

2021-01-13

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