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Search for antimicrobial activity among fifty-two natural and synthetic compounds identifies anthraquinone and polyacetylene classes that inhibit Mycobacterium tuberculosis
journal contribution
posted on 2023-06-09, 22:40 authored by Luiz A E Pollo, Erlon F Martin, Vanessa R Machado, Daire Cantillon, Leticia Muraro Wildner, Maria Luiza Bazzo, Simon WaddellSimon Waddell, Maique W Biavatti, Louis P SandjoDrug-resistant tuberculosis threatens to undermine global control programs by limiting treatment options. New antimicrobial drugs are required, derived from new chemical classes. Natural products offer extensive chemical diversity and inspiration for synthetic chemistry. Here, we isolate, synthesize and test a library of 52 natural and synthetic compounds for activity against Mycobacterium tuberculosis. We identify seven compounds as antimycobacterial, including the natural products isobavachalcone and isoneorautenol, and a synthetic chromene. The plant-derived secondary metabolite damnacanthal was the most active compound with the lowest minimum inhibitory concentration of 13.07 µg/mL and a favorable selectivity index value. Three synthetic polyacetylene compounds demonstrated antimycobacterial activity, with the lowest MIC of 17.88 µg/mL. These results suggest new avenues for drug discovery, expanding antimicrobial compound chemistries to novel anthraquinone and polyacetylene scaffolds in the search for new drugs to treat drug-resistant bacterial diseases.
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Publication status
- Published
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- Published version
Journal
Frontiers in MicrobiologyISSN
1664-302XPublisher
FrontiersExternal DOI
Volume
11Page range
1-11Article number
a622629Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-01-08First Open Access (FOA) Date
2021-01-21First Compliant Deposit (FCD) Date
2021-01-21Usage metrics
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