eaba2634.full.pdf (4.16 MB)
Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound
journal contribution
posted on 2023-06-09, 22:34 authored by Ian J Russell, Victoria A Lukashkina, Snezana LevicSnezana Levic, Young-Wook Cho, Andrei N Lukashkin, Lily Ng, Douglas ForrestThe detection of different frequencies in sound is accomplished with remarkable precision by the basilar membrane (BM), an elastic, ribbon-like structure with graded stiffness along the cochlear spiral. Sound stimulates a wave of displacement along the BM with maximal magnitude at precise, frequency-specific locations to excite neural signals that carry frequency information to the brain. Perceptual frequency discrimination requires fine resolution of this frequency map, but little is known of the intrinsic molecular features that demarcate the place of response on the BM. To investigate the role of BM microarchitecture in frequency discrimination, we deleted extracellular matrix protein emilin 2, which disturbed the filamentous organization in the BM. Emilin2-/- mice displayed broadened mechanical and neural frequency tuning with multiple response peaks that are shifted to lower frequencies than normal. Thus, emilin 2 confers a stiffness gradient on the BM that is critical for accurate frequency resolution.
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Publication status
- Published
File Version
- Published version
Journal
Science AdvancesISSN
2375-2548Publisher
American Association for the Advancement of ScienceExternal DOI
Issue
24Volume
6Page range
1-13Article number
eaba2634Event location
United StatesDepartment affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2021-01-05First Open Access (FOA) Date
2021-01-05First Compliant Deposit (FCD) Date
2021-01-05Usage metrics
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