Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound

Russell, Ian J, Lukashkina, Victoria A, Levic, Snezana, Cho, Young-Wook, Lukashkin, Andrei N, Ng, Lily and Forrest, Douglas (2020) Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound. Science Advances, 6 (24). eaba2634 1-13. ISSN 2375-2548

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Abstract

The detection of different frequencies in sound is accomplished with remarkable precision by the basilar membrane (BM), an elastic, ribbon-like structure with graded stiffness along the cochlear spiral. Sound stimulates a wave of displacement along the BM with maximal magnitude at precise, frequency-specific locations to excite neural signals that carry frequency information to the brain. Perceptual frequency discrimination requires fine resolution of this frequency map, but little is known of the intrinsic molecular features that demarcate the place of response on the BM. To investigate the role of BM microarchitecture in frequency discrimination, we deleted extracellular matrix protein emilin 2, which disturbed the filamentous organization in the BM. Emilin2-/- mice displayed broadened mechanical and neural frequency tuning with multiple response peaks that are shifted to lower frequencies than normal. Thus, emilin 2 confers a stiffness gradient on the BM that is critical for accurate frequency resolution.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 05 Jan 2021 10:01
Last Modified: 21 Jan 2021 11:15
URI: http://sro.sussex.ac.uk/id/eprint/95938

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