Excess mortality in severe mental illness: 10-Year population-based cohort study rural Ethiopia

Fekadu, Abebaw, Medhin, Girmay, Kebede, Derege, Alem, Atalay, Cleare, Anthony J, Prince, Martin, Hanlon, Charlotte and Shibre, Teshome (2015) Excess mortality in severe mental illness: 10-Year population-based cohort study rural Ethiopia. British Journal of Psychiatry, 206 (4). pp. 289-296. ISSN 0007-1250

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Abstract

Background
Evidence on mortality in severe mental illness (SMI) comes primarily from clinical samples in high-income countries.

Aims
To describe mortality in people with SMI among a population cohort from a low-income country.

Method
We followed-up 919 adults (from 68 378 screened) with SMI over 10 years. Standardised mortality ratios (SMR) and years of life lost (YLL) as a result of premature mortality were calculated.

Results
In total 121 patients (13.2%) died. The overall SMR was twice that of the general population; higher for men and people with schizophrenia. Patients died about three decades prematurely, mainly from infectious causes (49.6%). Suicide, accidents and homicide were also common causes of death.

Conclusions
Mortality is an important adverse outcome of SMI irrespective of setting. Addressing common natural and unnatural causes of mortality are urgent priorities. Premature death and mortality related to self-harm should be considered in the estimation of the global burden of disease for SMI.

Item Type: Article
Keywords: Accidents, Adolescent, Adult, Bipolar Disorder, Cause of Death, Cohort Studies, Depression, Ethiopia, Female, Homicide, Humans, Male, Middle Aged, Poverty, Rural Population, Schizophrenia, Sex Distribution, Suicide, Young Adult
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 04 Feb 2021 12:46
Last Modified: 04 Feb 2021 13:19
URI: http://sro.sussex.ac.uk/id/eprint/95934
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