Chem Eur J Temp Re-format for final submission.pdf (312.43 kB)
Batch versus flow photochemistry: a revealing comparison of yield and productivity
journal contribution
posted on 2023-06-09, 22:28 authored by Luke D Elliott, Jonathan P Knowles, Paul J Koovits, Katie G Maskill, Michael J Ralph, Guillaume Lejeune, Lee J Edwards, Richard I Robinson, Ian R Clemens, Brian Cox, David D Pascoe, Guido Koch, Martin Eberle, Malcolm B Berry, Kevin I Booker-MilburnThe use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups in recent years. To rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared. Surprisingly, yields were essentially identical in all comparative cases. Even more revealing was the observation that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched. Those with a single layer of fluorinated ethylene propylene (FEP) had an average productivity 20% lower than that of batch, whereas three-layer reactors were 20% more productive. Finally, the utility of flow chemistry was demonstrated in the scale-up of the ringopening reaction of a potentially explosive [1.1.1] propellane with butane-2,3-dione.
History
Publication status
- Published
File Version
- Accepted version
Journal
Chemistry - A European JournalISSN
0947-6539Publisher
WileyExternal DOI
Issue
46Volume
20Page range
15226-15232Event location
GermanyDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-12-18First Open Access (FOA) Date
2020-12-18First Compliant Deposit (FCD) Date
2020-12-15Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC