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Batch versus flow photochemistry: a revealing comparison of yield and productivity

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posted on 2023-06-09, 22:28 authored by Luke D Elliott, Jonathan P Knowles, Paul J Koovits, Katie G Maskill, Michael J Ralph, Guillaume Lejeune, Lee J Edwards, Richard I Robinson, Ian R Clemens, Brian Cox, David D Pascoe, Guido Koch, Martin Eberle, Malcolm B Berry, Kevin I Booker-Milburn
The use of flow photochemistry and its apparent superiority over batch has been reported by a number of groups in recent years. To rigorously determine whether flow does indeed have an advantage over batch, a broad range of synthetic photochemical transformations were optimized in both reactor modes and their yields and productivities compared. Surprisingly, yields were essentially identical in all comparative cases. Even more revealing was the observation that the productivity of flow reactors varied very little to that of their batch counterparts when the key reaction parameters were matched. Those with a single layer of fluorinated ethylene propylene (FEP) had an average productivity 20% lower than that of batch, whereas three-layer reactors were 20% more productive. Finally, the utility of flow chemistry was demonstrated in the scale-up of the ringopening reaction of a potentially explosive [1.1.1] propellane with butane-2,3-dione.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Chemistry - A European Journal

ISSN

0947-6539

Publisher

Wiley

Issue

46

Volume

20

Page range

15226-15232

Event location

Germany

Department affiliated with

  • Chemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-12-18

First Open Access (FOA) Date

2020-12-18

First Compliant Deposit (FCD) Date

2020-12-15

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