COX et al review.pdf (856.15 kB)
Escaping from flatland: [2 + 2] photocycloaddition; conformationally constrained sp3-rich scaffolds for lead generation
journal contribution
posted on 2023-06-09, 22:27 authored by Brian Cox, Kevin I Booker-Milburn, Luke D Elliott, Michael Robertson-Ralph, Victor ZdorichenkoPressure on researchers to deliver new medicines to the patient continues to grow. Attrition rates in the research and development process present a significant challenge to the viability of the current model of drug discovery. Analysis shows that increasing the three-dimensionality of potential drug candidates decreases the risk of attrition, and it is for this reason many workers have taken a new look at the power of photochemistry, in particular photocycloadditions, as a means to generate novel sp3-rich scaffolds for use in drug discovery programs. The viability of carrying out photochemical reactions on scale is also being addressed by the introduction of new technical developments.
History
Publication status
- Published
File Version
- Accepted version
Journal
ACS Medicinal Chemistry LettersISSN
1948-5875Publisher
American Chemical SocietyExternal DOI
Issue
11Volume
10Page range
1512-1517Event location
United StatesDepartment affiliated with
- Chemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-12-15First Open Access (FOA) Date
2020-12-15First Compliant Deposit (FCD) Date
2020-12-14Usage metrics
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