Dual-task performance in multiple sclerosis' patients: cerebellum matters?

Argento, Ornella, Spanò, Barbara, Pisani, Valerio, Incerti, Chiara C, Bozzali, Marco, Foti, Calogero, Caltagirone, Carlo and Nocentini, Ugo (2020) Dual-task performance in multiple sclerosis' patients: cerebellum matters? Archives of Clinical Neuropsychology. ISSN 0887-6177

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Abstract

Objective
Gait, cognitive impairments, and their mutual influence in dual tasking (cognitive–motor dual tasking, CM-DT) are important to address therapeutic approaches in patients with multiple sclerosis (PMS). CM-DT correlates have been widely investigated with variable and dissimilar results, due to differences in methods. However, although the cerebellum has recently shown to be involved in both motor and cognitive functions, few studies have explored its role in the integration of the concurrent execution of gait and cognition. This case–control study aims to explore the effects of adding a cognitive task to walking in PMS and to investigate the role of the cerebellum in the interfering process.

Methods
In total, 20 patients and 18 healthy controls (HC) underwent clinical assessments, dual task (DT), and 3 T magnetic resonance imaging (MRI). DT was composed by three 2-min trials requiring fast walking. In 2 of them 2 different cognitive tasks were added.

Results
Both groups evidenced the presence of cognitive–motor interference (CMI) for both cognitive conditions with a greater effect of word list generation task in PMS. Analysis of variance between HC and patients with high or low performances showed a significantly increased volume in Vermis lobules VIIIa and IX of high performers compared with HC.

Conclusion
Our results show that CMI is also present in healthy individuals but is significantly more disabling in PMS. Furthermore, MRI data point to the existence of an initial mechanism of cerebellar reorganization in PMS with lower interference. Subsequently, the failure of this mechanism due to the progression of disability leads to a more evident expression of symptoms.

Item Type: Article
Keywords: Multiple sclerosis, Neuroimaging (structural), Test construction
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 11 Dec 2020 15:28
Last Modified: 11 Dec 2020 15:28
URI: http://sro.sussex.ac.uk/id/eprint/95606

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