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A cross-sectional study to evaluate depression and quality of life among patients with lymphoedema due to podoconiosis, lymphatic filariasis and leprosy
Version 2 2023-06-12, 09:33
Version 1 2023-06-09, 21:59
journal contribution
posted on 2023-06-12, 09:33 authored by Oumer Ali, Kebede Kassaye, Maya SemrauMaya Semrau, Asrat Mengiste, Mersha Kinfe, Abraham Tesfaye, Stephen BremnerStephen Bremner, Gail DaveyGail Davey, Abebaw FekaduBackground Podoconiosis, lymphatic filariasis (LF) and leprosy are neglected tropical diseases (NTDs) that cause lymphoedema. When left untreated, they lead to substantial disability. This study determined the quality of life (QOL) and depression associated with lymphoedema in patients with podoconiosis, LF and leprosy. The study was conducted in northwestern Ethiopia. Methods This baseline cross-sectional study, nested within an interventional, non-comparative, longitudinal study, included patients with lymphoedema. Depression and QOL were assessed using versions of the 9-item Patient Health Questionnaire and Dermatologic Life Quality Index (DLQI), respectively, that had been translated into Amharic and validated. Factors associated with depression and QOL were assessed using multivariate linear regression analysis. Results Of the 251 patients with lymphoedema included in the study, 119 (47.4%) had moderate to severe depression and overall QOL was poor (mean±standard deviation [SD] DLQI score: 11.4±4.2). Disability was significantly associated with depression (ß=0.26 [95% confidence interval {CI} 0.19 to 0.33]). Currently receiving treatment (ß=-3.05 [95% CI -5.25 to -0.85), disability (ß=-0.08 [95% CI -0.15 to -0.01]) and social support (moderate support: ß=-2.27 [95% CI -3.66 to -0.89] and strong support: ß=-2.87 [95% CI -5.35 to -0.38]) were significantly associated with better QOL. Conclusion High levels of depression and low QOL were found among patients with lymphoedema due the three NTDs in Ethiopia.
History
Publication status
- Published
File Version
- Published version
Journal
Transactions of the Royal Society of Tropical Medicine and HygieneISSN
0035-9203Publisher
Oxford University PressExternal DOI
Issue
12Volume
114Page range
983-994Department affiliated with
- Global Health and Infection Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-10-27First Open Access (FOA) Date
2021-01-18First Compliant Deposit (FCD) Date
2020-10-28Usage metrics
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