fimmu-11-01987.pdf (152.09 kB)
Editorial: Translational insights into mechanisms and therapy of organ dysfunction in sepsis and trauma
journal contribution
posted on 2023-06-09, 21:41 authored by Peter Radermacher, Timothy R Billiar, Pietro Ghezzi, Lukas Martin, Christoph ThiemermannMultiple organ dysfunction or even failure after sepsis or trauma is due to a dysregulated host response. Currently, besides (surgical) source control (e.g., control of bleeding or drainage of abscesses) and administration of antimicrobial drugs, therapeutic approaches are limited to supportive care. Advances in our understanding of the key pathophysiological pathways involved in the excessive inflammation triggered by trauma, sepsis and/or ischemia-reperfusion have had limited impact. The 28 article in this Research Topic focus on the molecular mechanisms behind (hyper) inflammation after sepsis or trauma, with special emphasis on preclinical and translational studies that target potential organ-protective and/or -resuscitative therapeutic strategies. Most studies report rodent models of trauma and elective surgery (three articles), non-microbial hyper-inflammation induced with endotoxin exposure (LPS; seven articles) and chemical pancreatitis (one article), and cecal ligation and puncture-induced sepsis (six articles). Additional papers summarize investigations of human material (six articles) or fully-resuscitated large animal models (two articles). These article are complimented by four reviews and a commentary.
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- Published
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- Published version
Journal
Frontiers in ImmunologyISSN
1664-3224Publisher
Frontiers MediaExternal DOI
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11Page range
1-5Article number
a1987Department affiliated with
- Clinical and Experimental Medicine Publications
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- Yes
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- Yes
Legacy Posted Date
2020-09-28First Open Access (FOA) Date
2020-09-28First Compliant Deposit (FCD) Date
2020-09-28Usage metrics
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