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Pulmonary metastasectomy in colorectal cancer: health utility scores by EQ-5D-3L in a randomised controlled trial show no benefit from lung metastasectomy

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Version 2 2023-06-12, 09:29
Version 1 2023-06-09, 21:38
journal contribution
posted on 2023-06-12, 09:29 authored by Chris Brew-Graves, Vernon Farewell, Kathryn Monson, Mišel Miloševic, Norman R Williams, Eva Morris, Fergus Macbeth, Tom Treasure, Lesley FallowfieldLesley Fallowfield
Aim The aim was to assess the health utility of lung metastasectomy in the treatment of patients with colorectal cancer (CRC) using the EQ-5D-3L questionnaire. Methods Multidisciplinary CRC teams at 14 sites recruited patients to a two-arm randomized controlled trial—Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC). Remote randomization was used, stratified by site and with minimization for seven known confounders. Participants completed the EQ-5D-3L questionnaire together with other patient reported outcome measures at randomization and then again at 3, 6, 12 and 24 months. These were returned by post to the coordinating centre. Results Between December 2010 and December 2016, 93 participants were randomized, 91 of whom returned questionnaires. Survival and patient reported quality of life have been published previously, revealing no significant differences between the trial arms. Described here are patient reported data from the five dimensions of the EQ-5D-3L and the visual analogue scale (VAS) health state. No significant difference was seen at any time point. The estimated difference between control and metastasectomy patients was -0.23 (95% CI –0.113, 0.066) for the composite 0 to 1 index scale based on the descriptive system and 0.123 (95% CI –7.24, 7.49) for the 0 to 100 VAS scale. Conclusions Following lung metastasectomy for CRC, no benefit was demonstrated for health utility, which alongside a lack of a survival or quality of life benefit calls into question the widespread use of the procedure.

History

Publication status

  • Published

File Version

  • Published version

Journal

Colorectal Disease

ISSN

1462-8910

Publisher

Wiley

Page range

1-6

Department affiliated with

  • Sussex Health Outcomes Research & Education in Cancer (SHORE-C) Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2020-09-22

First Open Access (FOA) Date

2020-11-13

First Compliant Deposit (FCD) Date

2020-09-21

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