University of Sussex
Browse

File(s) not publicly available

The role of SMC proteins in the responses to DNA damage

journal contribution
posted on 2023-06-07, 13:52 authored by Alan LehmannAlan Lehmann
The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination.

History

Publication status

  • Published

Journal

DNA Repair

ISSN

1568-7864

Publisher

Elsevier

Issue

3

Volume

4

Page range

309-314

Notes

1568-7864 Journal Article GDSC121

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2007-03-19

Usage metrics

    University of Sussex (Publications)

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC