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The role of SMC proteins in the responses to DNA damage
The SMC proteins form the cores of three protein complexes in eukaryotes, cohesin, condensin and the Smc5-6 complex. Cohesin holds sister chromatids together after DNA replication and is involved in both the repair of double-strand breaks by homologous recombination and the intra-S-phase checkpoint. Condensin assists in the condensation of chromosomes at mitosis and also has a role in checkpoint control pathways. The Smc5-6 complex is involved in a variety of DNA repair and damage response pathways by as yet unknown mechanisms, but is also associated with repair by homologous recombination.
History
Publication status
- Published
Journal
DNA RepairISSN
1568-7864Publisher
ElsevierExternal DOI
Issue
3Volume
4Page range
309-314Notes
1568-7864 Journal Article GDSC121Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2007-03-19Usage metrics
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