Integrating actin and myosin II in a viscous model for cell migration

Madzvamuse, Anotida and Kipchumba Kiplangat, Benard (2020) Integrating actin and myosin II in a viscous model for cell migration. Frontiers in Applied Mathematics and Statistics, 6 (a26). pp. 1-17. ISSN 2297-4687

[img] PDF - Published Version
Available under License Creative Commons Attribution.

Download (2MB)


This article presents a mathematical and computational model for cell migration that couples a system of reaction-advection-diffusion equations describing the bio-molecular interactions between F-actin and myosin II to a force balance equation describing the structural mechanics of the actin-myosin network. In eukaryotic cells, cell migration is largely powered by a system of actin and myosin dynamics. We formulate the model equations on a two-dimensional cellular migrating evolving domain to take into account the convective and dilution terms for the biochemical reaction-diffusion equations, with hypothetically proposed reaction-kinetics. We employ the evolving finite element method to compute approximate numerical solutions of the coupled biomechanical model in two dimensions. Numerical experiments exhibit cell polarization through symmetry breaking which are driven by the F-actin and myosin II. This conceptual hypothetical proof-of-concept framework set premises for studying experimentally-driven actin-myosin reaction-kinetic network interactions with generalizations to multi-dimensions.

Item Type: Article
Keywords: cell migration, viscous model, reaction-advection-diffusion equations, force balance equation, evolving
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 09 Sep 2020 06:42
Last Modified: 24 Feb 2022 12:25

View download statistics for this item

📧 Request an update
Project NameSussex Project NumberFunderFunder Ref
InCeM: Research Training Network on Integrated Component Cycling in Epithelial Cell MotilityG1546EUROPEAN UNION642866 - InCeM
New predictive mathematical and computational models in experimental sciencesG1949ROYAL SOCIETYWM160017
Unravelling new mathematics for 3D cell migrationG1438LEVERHULME TRUSTRPG-2014-149