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Interaction of British Anti-Lewisite (BAL) with Copper(I) and Copper(II) compounds in conjunction with Wilson's disease
journal contribution
posted on 2023-06-09, 21:27 authored by Panayiotis V Ioannou, Rupert PurchaseThe chemistry of British Anti-Lewisite (BAL) and copper in relation to the therapeutic action for the treatment of Wilson's disease was studied by reacting selected Cu(I) and Cu(II) compounds with a range of thiol compounds. Optimum conditions for the preparation of cuprous mercaptides, CuI-SR, from thiophenol, 3-mercapto-1,2-propanediol (MPDH), cysteine (CysH), and glutathione (GSH), were established. BAL displaced Cu(I) from CuI-MPD giving CuI2-BAL irrespective of stoichiometry, while from CuI-cys and CuI-SG, Cu-BAL were obtained. BAL passivated CuI-SPh. The direct reaction of BAL with either Cu(II) or Cu(I) gave insoluble amorphous solids assumed to be CuI2-(oxidized dimeric BAL) or CuI2-BAL, respectively, that could not be completely analyzed or solubilized under various conditions. Thus, the detection of elevated copper in the urine ofWilson's disease patients treated with BAL may not be directly due to the solubilization of endogenous copper by BAL. Cuprous mercaptides are easily autoxidized by attack ofO2 to CuI to give CuII probably as peroxo complexes.
History
Publication status
- Published
Journal
Main Group ChemistryISSN
1024-1221Publisher
IOS PressExternal DOI
Issue
1Volume
17Page range
1-16Department affiliated with
- Chemistry Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2020-08-17Usage metrics
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