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Neuronal network topology indicates distinct recovery processes after stroke

Version 2 2023-06-07, 08:55
Version 1 2023-06-07, 07:41
journal contribution
posted on 2023-06-07, 08:55 authored by Shahrzad Latifi, Simon MitchellSimon Mitchell, Rouhollah Habibey, Fouzhan Hosseini, Elissa Donzis, Ana María Estrada-Sánchez, H Rezaei Nejad, Michael Levine, Peyman Golshani, S Thomas Carmichael
Despite substantial recent progress in network neuroscience, the impact of stroke on the distinct features of reorganizing neuronal networks during recovery has not been defined. Using a functional connections-based approach through 2-photon in vivo calcium imaging at the level of single neurons, we demonstrate for the first time the functional connectivity maps during motion and nonmotion states, connection length distribution in functional connectome maps and a pattern of high clustering in motor and premotor cortical networks that is disturbed in stroke and reconstitutes partially in recovery. Stroke disrupts the network topology of connected inhibitory and excitatory neurons with distinct patterns in these 2 cell types and in different cortical areas. These data indicate that premotor cortex displays a distinguished neuron-specific recovery profile after stroke.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Cerebral Cortex

ISSN

1047-3211

Publisher

Oxford University Press

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2020-08-04

First Open Access (FOA) Date

2021-07-30

First Compliant Deposit (FCD) Date

2020-08-05

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