Shibuya_Watanabe_65.pdf (2.48 MB)
The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis
journal contribution
posted on 2023-06-07, 07:27 authored by Hiroki Shibuya, Kei-ichiro Ishiguro, Yoshinori WatanabeDuring meiotic prophase, telomere-mediated chromosomal movement along the nuclear envelope is crucial for homologue pairing and synapsis. However, how telomeres are modified to mediate chromosome movement is largely elusive. Here we show that mammalian meiotic telomeres are fundamentally modified by a meiosis-specific Myb-domain protein, TERB1, that localizes at telomeres in mouse germ cells. TERB1 forms a heterocomplex with the canonical telomeric protein TRF1 and binds telomere repeat DNA. Disruption of Terb1 in mice abolishes meiotic chromosomal movement and impairs homologous pairing and synapsis, causing infertility in both sexes. TERB1 promotes telomere association with the nuclear envelope and deposition of the SUN–KASH complex, which recruits cytoplasmic motor complexes. TERB1 also binds and recruits cohesin to telomeres to develop structural rigidity, strikingly reminiscent of centromeres. Our study suggests that TERB1 acts as a central hub for the assembly of a conserved meiotic telomere complex required for chromosome movements
History
Publication status
- Published
File Version
- Accepted version
Journal
Nature Cell BiologyISSN
1465-7392Publisher
Nature ResearchExternal DOI
Issue
2Volume
16Page range
145-156Department affiliated with
- Sussex Centre for Genome Damage Stability Publications
Research groups affiliated with
- Genome Damage and Stability Centre Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-07-08First Open Access (FOA) Date
2020-07-09First Compliant Deposit (FCD) Date
2020-07-07Usage metrics
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