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Triggering mitosis

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journal contribution
posted on 2023-06-07, 07:26 authored by Adrijana Crncec, Helfrid HocheggerHelfrid Hochegger
Entry into mitosis is triggered by the activation of cyclin-dependent kinase 1 (Cdk1). This simple reaction rapidly and irreversibly sets the cell up for division. Even though the core step in triggering mitosis is so simple, the regulation of this cellular switch is highly complex, involving a large number of interconnected signalling cascades. We do have a detailed knowledge of most of the components of this network, but only a poor understanding of how they work together to create a precise and robust system that ensures that mitosis is triggered at the right time and in an orderly fashion. In this review, we will give an overview of the literature that describes the Cdk1 activation network and then address questions relating to the systems biology of this switch. How is the timing of the trigger controlled? How is mitosis insulated from interphase? What determines the sequence of events, following the initial trigger of Cdk1 activation? Which elements ensure robustness in the timing and execution of the switch? How has this system been adapted to the high levels of replication stress in cancer cells?

History

Publication status

  • Published

File Version

  • Accepted version

Journal

FEBS Letters

ISSN

0014-5793

Publisher

Wiley

Issue

20

Volume

593

Page range

2868-2888

Event location

England

Department affiliated with

  • Sussex Centre for Genome Damage Stability Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-07-07

First Open Access (FOA) Date

2020-10-11

First Compliant Deposit (FCD) Date

2020-07-07