Triggering mitosis

Crncec, Adrijana and Hochegger, Helfrid (2019) Triggering mitosis. FEBS Letters, 593 (20). pp. 2868-2888. ISSN 0014-5793

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Abstract

Entry into mitosis is triggered by the activation of cyclin‐dependent kinase 1 (Cdk1). This simple reaction rapidly and irreversibly sets the cell up for division. Even though the core step in triggering mitosis is so simple, the regulation of this cellular switch is highly complex, involving a large number of interconnected signalling cascades. We do have a detailed knowledge of most of the components of this network, but only a poor understanding of how they work together to create a precise and robust system that ensures that mitosis is triggered at the right time and in an orderly fashion. In this review, we will give an overview of the literature that describes the Cdk1 activation network and then address questions relating to the systems biology of this switch. How is the timing of the trigger controlled? How is mitosis insulated from interphase? What determines the sequence of events, following the initial trigger of Cdk1 activation? Which elements ensure robustness in the timing and execution of the switch? How has this system been adapted to the high levels of replication stress in cancer cells?

Item Type: Article
Keywords: Cdc25, Cdk1, Greatwall, Wee1, cell cycle;mitosis, Anaphase-Promoting Complex-Cyclosome, CDC2 Protein Kinase, Cell Cycle Proteins, Cell Line, Tumor, DNA Replication, Gene Expression Regulation, Humans, Mitosis, Neoplasms, Oocytes, Protein-Tyrosine Kinases, Signal Transduction, Systems Biology, Time Factors, cdc25 Phosphatases
Schools and Departments: School of Life Sciences > Sussex Centre for Genome Damage and Stability
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 07 Jul 2020 07:40
Last Modified: 11 Oct 2020 01:00
URI: http://sro.sussex.ac.uk/id/eprint/92380

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