CRNCECetal2019.pdf (430.17 kB)
Triggering mitosis
journal contribution
posted on 2023-06-07, 07:26 authored by Adrijana Crncec, Helfrid HocheggerHelfrid HocheggerEntry into mitosis is triggered by the activation of cyclin-dependent kinase 1 (Cdk1). This simple reaction rapidly and irreversibly sets the cell up for division. Even though the core step in triggering mitosis is so simple, the regulation of this cellular switch is highly complex, involving a large number of interconnected signalling cascades. We do have a detailed knowledge of most of the components of this network, but only a poor understanding of how they work together to create a precise and robust system that ensures that mitosis is triggered at the right time and in an orderly fashion. In this review, we will give an overview of the literature that describes the Cdk1 activation network and then address questions relating to the systems biology of this switch. How is the timing of the trigger controlled? How is mitosis insulated from interphase? What determines the sequence of events, following the initial trigger of Cdk1 activation? Which elements ensure robustness in the timing and execution of the switch? How has this system been adapted to the high levels of replication stress in cancer cells?
History
Publication status
- Published
File Version
- Accepted version
Journal
FEBS LettersISSN
0014-5793Publisher
WileyExternal DOI
Issue
20Volume
593Page range
2868-2888Event location
EnglandDepartment affiliated with
- Sussex Centre for Genome Damage Stability Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-07-07First Open Access (FOA) Date
2020-10-11First Compliant Deposit (FCD) Date
2020-07-07Usage metrics
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