s41467-020-16608-8.pdf (2.03 MB)
MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host
Version 2 2023-06-07, 08:49
Version 1 2023-06-07, 07:20
journal contribution
posted on 2023-06-07, 08:49 authored by Zhaojiang Guo, Shi Kang, Dan Sun, Lijun Gong, Junlei Zhou, Jianying Qin, Le Guo, Liuhong Zhu, Yang Bai, Fan Ye, Qingjun Wu, Shaoli Wang, Neil CrickmoreNeil Crickmore, Xuguo Zhou, Youjun ZhangThe arms race between entomopathogenic bacteria and their insect hosts is an excellent model for decoding the intricate coevolutionary processes of host-pathogen interaction. Here, we demonstrate that the MAPK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect host, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thuringiensis (Bt) toxins. Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elicit an important physiological response (i.e. Bt resistance) without incurring the significant fitness costs often associated with pathogen resistance. Hormones are well known to orchestrate physiological trade-offs in a wide variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones and suggests that hormonal signaling plasticity is a general cross-kingdom strategy to fend off pathogens.
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Publication status
- Published
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- Published version
Journal
Nature CommunicationsISSN
2041-1723Publisher
Nature ResearchExternal DOI
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11Page range
1-14Article number
a3003Department affiliated with
- Biochemistry Publications
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- No
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- Yes
Legacy Posted Date
2020-06-24First Open Access (FOA) Date
2020-06-24First Compliant Deposit (FCD) Date
2020-06-24Usage metrics
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