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MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host

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Version 2 2023-06-07, 08:49
Version 1 2023-06-07, 07:20
journal contribution
posted on 2023-06-07, 08:49 authored by Zhaojiang Guo, Shi Kang, Dan Sun, Lijun Gong, Junlei Zhou, Jianying Qin, Le Guo, Liuhong Zhu, Yang Bai, Fan Ye, Qingjun Wu, Shaoli Wang, Neil CrickmoreNeil Crickmore, Xuguo Zhou, Youjun Zhang
The arms race between entomopathogenic bacteria and their insect hosts is an excellent model for decoding the intricate coevolutionary processes of host-pathogen interaction. Here, we demonstrate that the MAPK signaling pathway is a general switch to trans-regulate differential expression of aminopeptidase N and other midgut genes in an insect host, diamondback moth (Plutella xylostella), thereby countering the virulence effect of Bacillus thuringiensis (Bt) toxins. Moreover, the MAPK cascade is activated and fine-tuned by the crosstalk between two major insect hormones, 20-hydroxyecdysone (20E) and juvenile hormone (JH) to elicit an important physiological response (i.e. Bt resistance) without incurring the significant fitness costs often associated with pathogen resistance. Hormones are well known to orchestrate physiological trade-offs in a wide variety of organisms, and our work decodes a hitherto undescribed function of these classic hormones and suggests that hormonal signaling plasticity is a general cross-kingdom strategy to fend off pathogens.

History

Publication status

  • Published

File Version

  • Published version

Journal

Nature Communications

ISSN

2041-1723

Publisher

Nature Research

Volume

11

Page range

1-14

Article number

a3003

Department affiliated with

  • Biochemistry Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2020-06-24

First Open Access (FOA) Date

2020-06-24

First Compliant Deposit (FCD) Date

2020-06-24

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