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Acute myeloid leukaemia in its niche: the bone marrow microenvironment in acute myeloid leukaemia
journal contribution
posted on 2023-06-07, 07:20 authored by E E Ladikou, H Sivaloganathan, Andrea PepperAndrea Pepper, Timothy ChevassutTimothy ChevassutPurpose of Review Acute myeloid leukaemia (AML) is a heterogeneous malignancy for which treatment options remain suboptimal. It is clear that a greater understanding of the biology of the AML niche will enable new therapeutic strategies to be developed in order to improve treatment outcomes for patients. Recent Findings Recent evidence has highlighted the importance of the bone marrow microenvironment in protecting leukaemia cells, and in particular leukaemic stem cells from chemotherapy-induced cell death. This includes mesenchymal stem cells supporting growth and preventing apoptosis, and altered action and secretion profiles of other niche components including adipocytes, endothelial cells and T cells. Summary Here, we provide a detailed overview of the current understanding of the AML bone marrow microenvironment. Clinical trials of agents that mobilise leukaemic stem cells from the bone marrow are currently ongoing and show early promise. Future challenges will involve combining these novel therapies targeted at the AML niche with conventional chemotherapy treatment.
Funding
How does SARS CoV-2 infect blood vessels?; G3146; UK RESEARCH AND INNOVATION; MR/V036750/1
Drug-induced selective lethality in populations of DNMT3A knockdown cells; G2782; WELLCOME TRUST; 218435/Z/19/Z
Mining the Wnt signalling-responsive surfaceome for drug targets in acute myeloid leukaemia; G3090; WELLCOME TRUST
In vitro modelling and therapeutic targeting of tumour cell migration in chronic lymphocytic leukaemia.; G2544; BLOODWISE
SUSSEX CANCER FUND FOR TREATMENT AND RESEARCH; G3106; SUSSEX CANCER FUND FOR TREATMENT AND RESEARCH
History
Publication status
- Published
File Version
- Published version
Journal
Current Oncology ReportsISSN
1523-3790Publisher
SpringerExternal DOI
Volume
22Page range
1-9Article number
a27Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2020-06-23First Open Access (FOA) Date
2020-06-23First Compliant Deposit (FCD) Date
2020-06-23Usage metrics
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