clinmed.2020-0146.full.pdf (105.33 kB)
The Renin-Angiotensin system – a therapeutic target in COVID-19?
journal contribution
posted on 2023-06-07, 07:20 authored by Beattie R H Sturrock, Kate Milne, Timothy ChevassutTimothy ChevassutCOVID-19, caused by infection with SARS-CoV-2, is a disease characterised by cough, fever and fatigue, which progresses to life-threatening lung injury in approximately 5% of patients. The SARS-CoV-2 virus enters the cell via ACE2. ACE2 is a component of the renin–angiotensin system (RAS) which has an important counterregulatory effect on the classical ACE-dependent pathway. Several antihypertensives increase ACE2 expression or activity, leading to concern that this may facilitate SARS-CoV-2 entry and worsen COVID-19 disease. However, ACE2 is protective against lung injury while ANG II (which is catabolised by ACE2) is associated with lung injury both in mice and humans. We propose that medications which inhibit the RAS ACE-dependent pathway may be beneficial in treating COVID-19 and should be explored in animal models and clinical trials. Here we give an overview of the RAS pathway with respect to COVID-19 and argue that strategies which manipulate this pathway might reduce the destructive lung manifestations of COVID-19 and improve patient outcomes.
Funding
Drug-induced selective lethality in populations of DNMT3A knockdown cells; G2782; WELLCOME TRUST; 218435/Z/19/Z
Mining the Wnt signalling-responsive surfaceome for drug targets in acute myeloid leukaemia; G3090; WELLCOME TRUST
How does SARS CoV-2 infect blood vessels?; G3146; UK RESEARCH AND INNOVATION; MR/V036750/1
Modelling and targeting Acute Myeloid Leukaemia cells in the Bone Marrow protective niche; G3106; SUSSEX CANCER FUND FOR TREATMENT AND RESEARCH
In vitro modelling and therapeutic targeting of tumour cell migration in chronic lymphocytic leukaemia.; G2544; BLOODWISE; 18005
History
Publication status
- Published
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- Published version
Journal
Clinical MedicineISSN
1470-2118Publisher
Royal College of PhysiciansExternal DOI
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1-4Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- No
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- Yes
Legacy Posted Date
2020-06-23First Open Access (FOA) Date
2021-05-16First Compliant Deposit (FCD) Date
2020-06-23Usage metrics
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