Chloroquine and COVID-19 – a potential game changer?

Sturrock, Beattie R H and Chevassut, Timothy J T (2020) Chloroquine and COVID-19 – a potential game changer? Clinical Medicine, 20 (3). pp. 278-281. ISSN 1470-2118

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Abstract

The novel coronavirus SARS-CoV-2, causing the disease COVID-19, first emerged in Wuhan, China in December 2019 and has now spread to 203 countries or territories, infected over 2 million people and caused over 133,000 deaths. There is an urgent need for specific treatments. One potential treatment is chloroquine and its derivatives, including hydroxychloroquine, which have both antiviral and anti-inflammatory effects. These compounds are effective against SARS-CoV-2 in vitro, but in vivo data are lacking. Although some encouraging outcomes have been reported, and these results have been received enthusiastically, we recommend careful and critical evaluation of current evidence only when all methods and data are available for peer review. Chloroquine is safe and cheap. However, further evidence from coordinated multicentre trials is required before it can be confidently said whether it is effective against the current pandemic.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Clinical and Experimental Medicine
Subjects: R Medicine
R Medicine > RM Therapeutics. Pharmacology
Depositing User: Timothy Chevassut
Date Deposited: 23 Jun 2020 13:01
Last Modified: 23 Jun 2020 13:01
URI: http://sro.sussex.ac.uk/id/eprint/92075

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