Quantifying the role of stochasticity in the development of autoimmune disease

Nicholson, Lindsay B, Blyuss, Konstantin B and Fatehi, Farzad (2020) Quantifying the role of stochasticity in the development of autoimmune disease. Cells, 9. a860 1-23. ISSN 2073-4409

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Abstract

In this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics. Stability analysis yields parameter regions associated with normal cell homeostasis, or sustained periodic oscillations. Variance of these oscillations and the effects of stochastic amplification are also explored. Theoretical results are complemented by experiments, in which experimental autoimmune uveoretinitis (EAU) was induced in B10.RIII and C57BL/6 mice. For both cases, we discuss peculiarities of disease development, the levels of variation in T cell populations in a population of genetically identical organisms, as well as a comparison with model outputs.

Item Type: Article
Schools and Departments: School of Mathematical and Physical Sciences > Mathematics
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 26 May 2020 08:43
Last Modified: 26 May 2020 08:45
URI: http://sro.sussex.ac.uk/id/eprint/91363

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