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Graphene-induced transdifferentiation of cancer stem cells as a therapeutic strategy against glioblastoma

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posted on 2023-06-07, 07:00 authored by Costanza Martelli, Alice KingAlice King, Thomas Simon, Georgios GiamasGeorgios Giamas
Glioblastoma (GBM) is an extremely malignant tumor of the central nervous system, characterized by low response to treatments and reoccurrence. This therapeutic resistance is believed to arise mostly from the presence of a subpopulation of tumorigenic stem cells, known as cancer stem cells (CSCs). In addition, the surrounding microenvironment is known to maintain CSCs, thus supporting tumor development and aggressiveness. This review focuses on a therapeutic strategy involving the stem cell trans-differentiating ability of graphene and its derivatives. Graphene distinguishes itself from other carbon-based nanomaterials due to an array of properties that makes it suitable for many purposes, from bioengineering to biomedical applications. Studies have shown that graphene is able to promote and direct the differentiation of CSCs. In addition, potential usage of graphene in GBM treatment represents a challenge in respect to its administration method. The present review also provides a general outlook of the potential side effects (e.g., cell toxicity) that graphene could have. Overall, this report discusses certain graphene-based therapeutic strategies targeting CSCs, which can be considered as prospective effective GBM treatments.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

ACS Biomaterials Science & Engineering

ISSN

2373-9878

Publisher

American Chemical Society

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-05-15

First Open Access (FOA) Date

2021-04-21

First Compliant Deposit (FCD) Date

2020-05-15

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