Effect of propolis intake on serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) levels in adults: a systematic review and meta-analysis of clinical trials

Jalali, Mohammad, Ranjbar, Tahereh, Mosallanezhad, Zahra, Mahmoodi, Marzieh, Moosavian, Seyedeh Parisa, Ferns, Gordon A, Jalali, Ronak and Sohrabi, Zahra (2020) Effect of propolis intake on serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) levels in adults: a systematic review and meta-analysis of clinical trials. Complementary Therapies in Medicine, 50. a102380. ISSN 0965-2299

[img] PDF - Accepted Version
Restricted to SRO admin only until 24 March 2021.
Available under License Creative Commons Attribution-NonCommercial No Derivatives.

Download (683kB)

Abstract

Background
Propolis is a natural Product and the antioxidant properties of Propolis appear to be principally responsible for its therapeutic effects. However, several studies have shown the positive effect of Propolis on the reduction the levels of inflammatory markers; some others have revealed non-significant impacts on them. Hence, the present systematic review and meta-analysis aimed to investigate the effects of Propolis intake on C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α).

Methods
The systematic search was undertaken in scientific databases that included: PubMed, Embase, Scopus and Web of Science to find studies assessing the effects of Propolis on CRP and TNF-α up to December 2019. Standardized mean difference (SMD) and 95 % confidence intervals (CI) were pooled using a random-effects model. Potential publication bias was tested using Egger’s test.

Results
Six studies comprising 406 participants were included in the meta-analysis. Compared to controls, Propolis intake significantly reduced serum TNF-α (SMD = −0.48, 95 % CI = [−0.69, −0.26], P < 0.0001, I2 = 66.9 %) and CRP (SMD = −0.38, 95 % CI = [−0.68, −0.07], P = 0.01, I2 = 44.4 %) levels. No evidence of publication bias was found in the meta-analyses.

Conclusion
The present study concluded in the statistically and clinically reduction of serum CRP and TNF-α levels following Propolis intake.

Item Type: Article
Keywords: Propolis, Nutrients, Inflammatory markers, Meta-analysis
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Cherie Elody
Date Deposited: 12 May 2020 06:48
Last Modified: 12 May 2020 07:00
URI: http://sro.sussex.ac.uk/id/eprint/91197

View download statistics for this item

📧 Request an update