Carbohydrate_accepted.pdf (1.03 MB)
Investigation of water vapour sorption mechanism of starch-based pharmaceutical excipients
journal contribution
posted on 2023-06-07, 06:56 authored by Saeid Rajabnezhad, Taravat Ghafourian, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Majid Naderi, Jonathan P Salvage, Ali NokhodchiStarch-based excipients are commonly used in oral solid dosage forms. The effect of particle size and pregelatinisation level of starch-based excipients on their water absorption behaviour have been evaluated. The results showed that starch-based excipients have type ii isotherms, indicating that the principal mechanism of sorption is the formation of monolayer coverage and multilayer water molecules (10–80 RH %). It was found that the particle size of starch-based excipients did not have any influence on the rate of water sorption, whereas the level of pregelatinisation changed the kinetics of water sorption-desorption. Results showed that the higher the degree of pregelatinisation, the higher the rate of water absorption, which is irrespective of particle size. SEM images showed that a partially gelatinised starch had a firm granular structure with small pores and channels on the surface while a fully gelatinised starch had more irregular and spongy like surface with a degree of fractured particles.
History
Publication status
- Published
File Version
- Accepted version
Journal
Carbohydrate PolymersISSN
0144-8617Publisher
ElsevierExternal DOI
Volume
238Article number
a116208Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-05-04First Open Access (FOA) Date
2021-03-24First Compliant Deposit (FCD) Date
2020-05-04Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC