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Investigation of water vapour sorption mechanism of starch-based pharmaceutical excipients

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journal contribution
posted on 2023-06-07, 06:56 authored by Saeid Rajabnezhad, Taravat Ghafourian, Ali Rajabi-Siahboomi, Shahrzad Missaghi, Majid Naderi, Jonathan P Salvage, Ali Nokhodchi
Starch-based excipients are commonly used in oral solid dosage forms. The effect of particle size and pregelatinisation level of starch-based excipients on their water absorption behaviour have been evaluated. The results showed that starch-based excipients have type ii isotherms, indicating that the principal mechanism of sorption is the formation of monolayer coverage and multilayer water molecules (10–80 RH %). It was found that the particle size of starch-based excipients did not have any influence on the rate of water sorption, whereas the level of pregelatinisation changed the kinetics of water sorption-desorption. Results showed that the higher the degree of pregelatinisation, the higher the rate of water absorption, which is irrespective of particle size. SEM images showed that a partially gelatinised starch had a firm granular structure with small pores and channels on the surface while a fully gelatinised starch had more irregular and spongy like surface with a degree of fractured particles.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Carbohydrate Polymers

ISSN

0144-8617

Publisher

Elsevier

Volume

238

Article number

a116208

Department affiliated with

  • Biochemistry Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-05-04

First Open Access (FOA) Date

2021-03-24

First Compliant Deposit (FCD) Date

2020-05-04

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