Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis

Christoforidou, Eleni, Joilin, Greig and Hafezparast, Majid (2020) Potential of activated microglia as a source of dysregulated extracellular microRNAs contributing to neurodegeneration in amyotrophic lateral sclerosis. Journal of Neuroinflammation, 17 (a135). pp. 1-15. ISSN 1742-2094

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Abstract

Amyotrophic lateral sclerosis (ALS) is the most common form of motor neuron degeneration in adults, and several mechanisms underlying the disease pathology have been proposed. It has been shown that glia communicate with other cells by releasing extracellular vesicles containing proteins and nucleic acids, including microRNAs (miRNAs), which play a role in the post-transcriptional regulation of gene expression. Dysregulation of miRNAs is commonly observed in ALS patients, together with inflammation and an altered microglial phenotype. However, the role of miRNA-containing vesicles in microglia-to-neuron communication in the context of ALS has not been explored in depth. This review summarises the evidence for the presence of inflammation, pro-inflammatory microglia and dysregulated miRNAs in ALS, then explores how microglia may potentially be responsible for this miRNA dysregulation. The possibility of pro-inflammatory ALS microglia releasing miRNAs which may then enter neuronal cells to contribute to degeneration is also explored. Based on the literature reviewed here, microglia are a likely source of dysregulated miRNAs and potential mediators of neurodegenerative processes. Therefore, dysregulated miRNAs may be promising candidates for the development of therapeutic strategies.

Item Type: Article
Keywords: Amyotrophic lateral sclerosis, motor neurone disease, neuroinflammation, microglia, microRNA
Schools and Departments: School of Life Sciences > Neuroscience
Research Centres and Groups: Sussex Neuroscience
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Depositing User: Majid Hafezparast
Date Deposited: 29 Apr 2020 07:44
Last Modified: 29 Apr 2020 07:45
URI: http://sro.sussex.ac.uk/id/eprint/91078

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Project NameSussex Project NumberFunderFunder Ref
Confirming a set of newly identified non-coding RNA biomarkers for amyotrophic lateral sclerosis and investigating their functional relevance to the disease.G2429MNDA-MOTOR NEURONE DISEASE ASSOCIATIONHafezparast/Apr18/861-791
Identification of non-coding RNA biomarkers from serum and cerebrospinal fluid for use as biomarkers in amyotrophic lateral sclerosis patientsG1722MNDA-MOTOR NEURONE DISEASE ASSOCIATIONHAFEZPARAST/APR15/836-791