Systematic review and network meta-analysis with individual participant data on cord management at preterm birth.pdf (1.2 MB)
Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol
journal contribution
posted on 2023-06-07, 06:53 authored by Anna Lene Seidler, Lelia Duley, Anup C Katheria, Catalina De Paco Mattallana, Eugene Dempsey, Heike RabeHeike Rabe, John Kattwinkel, Judith Mercer, Justin Josephsen, Karen Fairchild, Ola Andersson, Shigeharu Hosono, Venkataseshan Sundaram, Vikram Datta, Walid El-Naggar, iCOMP Collaboration, othersIntroduction Timing of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups. Previous and current trials compare various policies, including time-based or physiology-based deferred cord clamping, and cord milking. Individual participant data (IPD) enable exploration of different strategies within subgroups. Network meta-analysis (NMA) enables comparison and ranking of all available interventions using a combination of direct and indirect comparisons. Objectives (1) To evaluate the effectiveness of cord management strategies for preterm infants on neonatal mortality and morbidity overall and for different participant characteristics using IPD meta-analysis. (2) To evaluate and rank the effect of different cord management strategies for preterm births on mortality and other key outcomes using NMA. Methods and analysis Systematic searches of Medline, Embase, clinical trial registries, and other sources for all ongoing and completed randomised controlled trials comparing cord management strategies at preterm birth (before 37 weeks’ gestation) have been completed up to 13 February 2019, but will be updated regularly to include additional trials. IPD will be sought for all trials; aggregate summary data will be included where IPD are unavailable. First, deferred clamping and cord milking will be compared with immediate clamping in pairwise IPD meta-analyses. The primary outcome will be death prior to hospital discharge. Effect differences will be explored for prespecified participant subgroups. Second, all identified cord management strategies will be compared and ranked in an IPD NMA for the primary outcome and the key secondary outcomes. Treatment effect differences by participant characteristics will be identified. Inconsistency and heterogeneity will be explored. Ethics and dissemination Ethics approval for this project has been granted by the University of Sydney Human Research Ethics Committee (2018/886). Results will be relevant to clinicians, guideline developers and policy-makers, and will be disseminated via publications, presentations and media releases.
History
Publication status
- Published
File Version
- Published version
Journal
BMJ OpenISSN
1759-2151Publisher
BMJ Publishing GroupExternal DOI
Issue
3Volume
10Page range
1-12Department affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-04-29First Open Access (FOA) Date
2020-04-29First Compliant Deposit (FCD) Date
2020-04-29Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC