Breast PI3K regulatory miRNAs.pdf (328.55 kB)
Role of regulatory miRNAs of the PI3K/AKT signaling pathway in the pathogenesis of breast cancer
journal contribution
posted on 2023-06-09, 21:06 authored by Farzad Rahmani, Gordon FernsGordon Ferns, Sahar Talebian, Mahnaz Nourbakhsh, Amir Avan, Soodabeh ShahidsalesBreast cancer is one of the most common tumors in women. Current data indicate that the overexpression of some microRNAs (miRNAs) is associated with breast cancer, in relation to stage, tumor size and potential for metastasis. Some studies have reported that miRNAs have critical roles in cellular processes implicated in breast cancer cell growth, migration and metastasis by targeting the PI3K/AKT oncogenic signaling pathway. Therefore, identifying novel regulatory miRNAs for this oncogenic pathway and discovery of their related target genes may represent a promising therapeutic approach for breast cancer therapy. This review highlights the recent findings about the potential role of PI3K/AKT signaling regulatory miRNAs in breast cancer tumorigenesis.
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Publication status
- Published
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- Accepted version
Journal
GeneISSN
0378-1119Publisher
ElsevierExternal DOI
Volume
737Article number
a144459Department affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-04-20First Open Access (FOA) Date
2021-02-09First Compliant Deposit (FCD) Date
2020-04-17Usage metrics
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