Role of regulatory miRNAs of the PI3K/AKT signaling pathway in the pathogenesis of breast cancer

Rahmani, Farzad, Ferns, Gordon A, Talebian, Sahar, Nourbakhsh, Mahnaz, Avan, Amir and Shahidsales, Soodabeh (2020) Role of regulatory miRNAs of the PI3K/AKT signaling pathway in the pathogenesis of breast cancer. Gene, 737. a144459. ISSN 0378-1119

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Abstract

Breast cancer is one of the most common tumors in women. Current data indicate that the overexpression of some microRNAs (miRNAs) is associated with breast cancer, in relation to stage, tumor size and potential for metastasis. Some studies have reported that miRNAs have critical roles in cellular processes implicated in breast cancer cell growth, migration and metastasis by targeting the PI3K/AKT oncogenic signaling pathway. Therefore, identifying novel regulatory miRNAs for this oncogenic pathway and discovery of their related target genes may represent a promising therapeutic approach for breast cancer therapy. This review highlights the recent findings about the potential role of PI3K/AKT signaling regulatory miRNAs in breast cancer tumorigenesis.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Division of Medical Education
Depositing User: Cherie Elody
Date Deposited: 20 Apr 2020 06:37
Last Modified: 20 Apr 2020 07:00
URI: http://sro.sussex.ac.uk/id/eprint/90838

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