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Role of regulatory miRNAs of the PI3K/AKT signaling pathway in the pathogenesis of breast cancer

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journal contribution
posted on 2023-06-09, 21:06 authored by Farzad Rahmani, Gordon FernsGordon Ferns, Sahar Talebian, Mahnaz Nourbakhsh, Amir Avan, Soodabeh Shahidsales
Breast cancer is one of the most common tumors in women. Current data indicate that the overexpression of some microRNAs (miRNAs) is associated with breast cancer, in relation to stage, tumor size and potential for metastasis. Some studies have reported that miRNAs have critical roles in cellular processes implicated in breast cancer cell growth, migration and metastasis by targeting the PI3K/AKT oncogenic signaling pathway. Therefore, identifying novel regulatory miRNAs for this oncogenic pathway and discovery of their related target genes may represent a promising therapeutic approach for breast cancer therapy. This review highlights the recent findings about the potential role of PI3K/AKT signaling regulatory miRNAs in breast cancer tumorigenesis.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Gene

ISSN

0378-1119

Publisher

Elsevier

Volume

737

Article number

a144459

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-04-20

First Open Access (FOA) Date

2021-02-09

First Compliant Deposit (FCD) Date

2020-04-17

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