Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo

Yoshimatsu, Takeshi, D'Orazi, Florence D, Gamlin, Clare R, Suzuki, Sachihiro C, Suli, Arminda, Kimelman, David, Raible, David W and Wong, Rachel O (2016) Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo. Nature Communications, 7. p. 10590. ISSN 2041-1723

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Abstract

Whether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage.

Item Type: Article
Keywords: Animals, Cues, Dendrites, Immunohistochemistry, Microscopy, Confocal, Optical Imaging, Regeneration, Retinal Cone Photoreceptor Cells, Retinal Horizontal Cells, Retinal Neurons, Synapses, Ultraviolet Rays, Zebrafish
Schools and Departments: School of Life Sciences > Neuroscience
SWORD Depositor: Mx Elements Account
Depositing User: Mx Elements Account
Date Deposited: 24 Mar 2020 17:01
Last Modified: 07 Apr 2020 16:13
URI: http://sro.sussex.ac.uk/id/eprint/90538

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