Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo.pdf (2.23 MB)
Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo
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posted on 2023-06-09, 20:56 authored by Takeshi YoshimatsuTakeshi Yoshimatsu, Florence D D'Orazi, Clare R Gamlin, Sachihiro C Suzuki, Arminda Suli, David Kimelman, David W Raible, Rachel O WongWhether neurons can restore their original connectivity patterns during circuit repair is unclear. Taking advantage of the regenerative capacity of zebrafish retina, we show here the remarkable specificity by which surviving neurons reassemble their connectivity upon regeneration of their major input. H3 horizontal cells (HCs) normally avoid red and green cones, and prefer ultraviolet over blue cones. Upon ablation of the major (ultraviolet) input, H3 HCs do not immediately increase connectivity with other cone types. Instead, H3 dendrites retract and re-extend to contact new ultraviolet cones. But, if regeneration is delayed or absent, blue-cone synaptogenesis increases and ectopic synapses are made with red and green cones. Thus, cues directing synapse specificity can be maintained following input loss, but only within a limited time period. Further, we postulate that signals from the major input that shape the H3 HC's wiring pattern during development persist to restrict miswiring after damage.
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Publication status
- Published
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- Published version
Journal
Nature CommunicationsISSN
2041-1723Publisher
Nature ResearchExternal DOI
Volume
7Page range
10590Event location
EnglandDepartment affiliated with
- Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-03-24First Open Access (FOA) Date
2020-03-24First Compliant Deposit (FCD) Date
2020-03-24Usage metrics
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