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The role of double-strand break repair - insights from human genetics

journal contribution
posted on 2023-06-07, 13:52 authored by Mark O'DriscollMark O'Driscoll, Penny Jeggo
The efficient repair of DNA double-strand breaks is crucial in safeguarding the genomic integrity of organisms. Responses to double-strand breaks include complex signal-transduction, cell-cycle-checkpoint and repair pathways. Defects in these pathways lead to several human disorders with pleiotropic clinical features. Dissection of the molecular basis that underlies the diverse clinical features is enhancing our understanding of the damage-response mechanisms and their role in development, and might ultimately facilitate treatment.

History

Publication status

  • Published

Journal

Nature Reviews Genetics

ISSN

1471-0056

Publisher

Nature Publishing Group

Issue

1

Volume

7

Page range

45-54

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2007-03-16

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