Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study

Hoile, Richard, Tabet, Naji, Smith, Helen, Bremner, Stephen, Cassell, Jackie and Ford, Elizabeth (2019) Are symptoms of insomnia in primary care associated with subsequent onset of dementia? A matched retrospective case-control study. Aging & Mental Health. pp. 1-6. ISSN 1360-7863

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Abstract

Objective: There is evidence from neuroimaging studies of an association between insomnia and early dementia biomarkers, but observational studies have so far failed to show a clear association between insomnia and the later development of dementia. We investigated the association between dementia diagnosis and recording of insomnia symptoms 5-10 years earlier in primary care.

Method: A case-control study using data from the Clinical Practice Research Datalink. 15,209 cases with dementia (either Alzheimer's, vascular, mixed or non-specific subtypes) at least 65 years old at time of diagnosis, were matched with the same number of controls on year of birth and gender. We ascertained the presence of insomnia symptoms during a five-year period starting 10 years before the index date. Odds ratios for developing dementia were estimated using logistic regression after controlling for hypnotic exposure and physical and mental health comorbidities.

Results: The adjusted odds ratio for dementia in those with previous insomnia was 1.34 (95% CI = 1.20-1.50).

Conclusion: There is an association between dementia and previous insomnia. It may be possible to incorporate insomnia into predictive tools for dementia.

Item Type: Article
Keywords: dementia, Alzheimer's, insomnia, sleep, prediction
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Neuroscience
Brighton and Sussex Medical School > Primary Care and Public Health
Research Centres and Groups: Dementia Research Group
Subjects: R Medicine > R Medicine (General) > R864 Medical records
R Medicine > RC Internal medicine > RC0321 Neurosciences. Biological psychiatry. Neuropsychiatry > RC0346 Neurology. Diseases of the nervous system Including speech disorders
Depositing User: Naji Tabet
Date Deposited: 24 Feb 2020 09:01
Last Modified: 11 Mar 2020 12:38
URI: http://sro.sussex.ac.uk/id/eprint/90060

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