Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Al-Shahi Salman, Rustam, Minks, David P, Mitra, Dipayan, Rodrigues, Mark A, Bhatnagar, Priya, du Plessis, Johann C, Joshi, Yogish, Dennis, Martin S, Murray, Gordon D, Newby, David E, Sandercock, Peter A G, Sprigg, Nikola, Stephen, Jacqueline, Sudlow, Cathie L M, Werring, David J, Whiteley, William N, Wardlaw, Joanna M and White, Philip M (2019) Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial. Lancet Neurology, 18 (7). pp. 643-652. ISSN 1474-4422

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Abstract

Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Depositing User: Angela Blazey
Date Deposited: 19 Mar 2020 14:18
Last Modified: 19 Mar 2020 14:20
URI: http://sro.sussex.ac.uk/id/eprint/90003

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