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The effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta-analysis of clinical trials

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posted on 2023-06-09, 20:39 authored by Mohammad Jalali, Marzieh Mahmoodi, Seyedeh Parisa Moosavian, Ronak Jalali, Gordon FernsGordon Ferns, Abdolhamid Mosallanezhad, Mohammad Hadi Imanieh, Zahra Mosallanezhad
The present systematic review and meta-analysis was conducted to investigate the effects of ginger supplementation on markers of inflammatory and oxidative stress. PubMed, Embase, Scopus and Web of Science were systematically searched to identify relevant clinical trials evaluating the effects of ginger on serum CRP (C-reactive protein), TNF-a (tumor necrosis factor-alpha), IL-6 (interleukin-6), PGE2 (Prostaglandin E2), TAC (Total antioxidant capacity) and MDA (Malondialdehyde) from inception up to September 2019. Mean difference (MD) and its 95 % confidence interval (CI) was determined using a random effects model. Potential publication bias was assessed using visual inspection of funnel plot and Egger's weighted regression tests. After excluding irrelevant records, 20 full-text articles that included 25 separate studies were included to the meta-analysis. Pooled results of the present study indicated a statistically significant effect of ginger on serum CRP, TNF-a, IL-6, TAC and MDA levels following ginger supplementation. Also, the effects of ginger on serum PGE2 was marginally significant. Moreover, the significant heterogeneity disappeared in subgroup analysis performed by age, duration, dosage, and quality. This current analysis indicates that ginger supplementation has significant effects on serum inflammatory markers.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Phytotherapy Research

ISSN

0951-418X

Publisher

Wiley

Department affiliated with

  • Division of Medical Education Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-02-18

First Open Access (FOA) Date

2021-03-09

First Compliant Deposit (FCD) Date

2020-02-17

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