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The effects of ginger supplementation on markers of inflammatory and oxidative stress: a systematic review and meta-analysis of clinical trials
journal contribution
posted on 2023-06-09, 20:39 authored by Mohammad Jalali, Marzieh Mahmoodi, Seyedeh Parisa Moosavian, Ronak Jalali, Gordon FernsGordon Ferns, Abdolhamid Mosallanezhad, Mohammad Hadi Imanieh, Zahra MosallanezhadThe present systematic review and meta-analysis was conducted to investigate the effects of ginger supplementation on markers of inflammatory and oxidative stress. PubMed, Embase, Scopus and Web of Science were systematically searched to identify relevant clinical trials evaluating the effects of ginger on serum CRP (C-reactive protein), TNF-a (tumor necrosis factor-alpha), IL-6 (interleukin-6), PGE2 (Prostaglandin E2), TAC (Total antioxidant capacity) and MDA (Malondialdehyde) from inception up to September 2019. Mean difference (MD) and its 95 % confidence interval (CI) was determined using a random effects model. Potential publication bias was assessed using visual inspection of funnel plot and Egger's weighted regression tests. After excluding irrelevant records, 20 full-text articles that included 25 separate studies were included to the meta-analysis. Pooled results of the present study indicated a statistically significant effect of ginger on serum CRP, TNF-a, IL-6, TAC and MDA levels following ginger supplementation. Also, the effects of ginger on serum PGE2 was marginally significant. Moreover, the significant heterogeneity disappeared in subgroup analysis performed by age, duration, dosage, and quality. This current analysis indicates that ginger supplementation has significant effects on serum inflammatory markers.
History
Publication status
- Published
File Version
- Accepted version
Journal
Phytotherapy ResearchISSN
0951-418XPublisher
WileyExternal DOI
Department affiliated with
- Division of Medical Education Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-02-18First Open Access (FOA) Date
2021-03-09First Compliant Deposit (FCD) Date
2020-02-17Usage metrics
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