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Cerebellar white matter disruption in Alzheimer’s Disease patients: a Diffusion Tensor Imaging study

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posted on 2023-06-09, 20:39 authored by Sofia Toniolo, Laura Serra, Giusy Olivito, Carlo Caltagirone, Nicola B Mercuri, Camillo Marra, Mara Cercignani, Marco Bozzali
The cognitive role of the cerebellum has recently gained much attention, and its pivotal role in Alzheimer’s disease (AD) has now been widely recognized. Diffusion tensor imaging (DTI) has been used to evaluate the disruption of the microstructural milieu in AD, and though several white matter (WM) tracts such as corpus callosum, inferior and superior longitudinal fasciculus, cingulum, fornix, and uncinate fasciculus have been evaluated in AD, data on cerebellar WM tracts are currently lacking. We performed a tractography-based DTI reconstruction of the middle cerebellar peduncle (MCP), and the left and right superior cerebellar peduncles separately (SCPL and SCPR) and addressed the differences in fractional anisotropy (FA), axial diffusivity (Dax), radial diffusivity (RD), and mean diffusivity (MD) in the three tracts between 50 patients with AD and 25 healthy subjects. We found that AD patients showed a lower FA and a higher RD compared to healthy subjects in MCP, SCPL, and SCPR. Moreover, a higher MD was found in SCPR and SCPL and a higher Dax in SCPL. This result is important as it challenges the traditional view that WM bundles in the cerebellum are unaffected in AD and might identify new targets for therapeutic interventions.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Alzheimer's Disease

ISSN

1387-2877

Publisher

IOS Press

Page range

1-10

Department affiliated with

  • BSMS Neuroscience Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-02-18

First Open Access (FOA) Date

2023-05-25

First Compliant Deposit (FCD) Date

2023-05-25

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