Ghezzi_Rev1.pdf (1.19 MB)
How the redox state regulates immunity
journal contribution
posted on 2023-06-09, 20:38 authored by Lisa MullenLisa Mullen, Manuela MengozziManuela Mengozzi, Eva-Maria Hanschmann, Ben Alberts, Pietro GhezziOxidative stress is defined as an imbalance beween the levels of reactive oxygen species (ROS) and antioxidant defences. The view of oxidative stress as a cause of cell damage has evolved over the past few decades to a much more nuanced view of the role of oxidative changes in cell physiology. This is no more evident than in the field of immunity, where oxidative changes are now known to regulate many aspects of the immune response, and inflammatory pathways in particular. Our understanding of redox regulation of immunity now encompasses not only increases in reactive oxygen and nitrogen species, but also changes in the activities of oxidoreductase enzymes. These enzymes are important regulators of immune pathways both via changes in their redox activity, but also via other more recently identified cytokine-like functions. The emerging picture of redox regulation of immune pathways is one of increasing complexity and while therapeutic targeting of the redox environment to treat inflammatory disease is a possibility, any such strategy is likely to be more nuanced than simply inhibiting ROS production.
History
Publication status
- Published
File Version
- Accepted version
Journal
Free Radical Biology and MedicineISSN
0891-5849Publisher
ElsevierDepartment affiliated with
- Clinical and Experimental Medicine Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-02-18First Open Access (FOA) Date
2020-12-31First Compliant Deposit (FCD) Date
2020-02-18Usage metrics
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