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How the redox state regulates immunity

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posted on 2023-06-09, 20:38 authored by Lisa MullenLisa Mullen, Manuela MengozziManuela Mengozzi, Eva-Maria Hanschmann, Ben Alberts, Pietro Ghezzi
Oxidative stress is defined as an imbalance beween the levels of reactive oxygen species (ROS) and antioxidant defences. The view of oxidative stress as a cause of cell damage has evolved over the past few decades to a much more nuanced view of the role of oxidative changes in cell physiology. This is no more evident than in the field of immunity, where oxidative changes are now known to regulate many aspects of the immune response, and inflammatory pathways in particular. Our understanding of redox regulation of immunity now encompasses not only increases in reactive oxygen and nitrogen species, but also changes in the activities of oxidoreductase enzymes. These enzymes are important regulators of immune pathways both via changes in their redox activity, but also via other more recently identified cytokine-like functions. The emerging picture of redox regulation of immune pathways is one of increasing complexity and while therapeutic targeting of the redox environment to treat inflammatory disease is a possibility, any such strategy is likely to be more nuanced than simply inhibiting ROS production.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Free Radical Biology and Medicine

ISSN

0891-5849

Publisher

Elsevier

Department affiliated with

  • Clinical and Experimental Medicine Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2020-02-18

First Open Access (FOA) Date

2020-12-31

First Compliant Deposit (FCD) Date

2020-02-18

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