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Hippocampal-dependent appetitive control is impaired by experimental exposure to a Western-style diet

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Version 2 2023-06-12, 09:20
Version 1 2023-06-09, 20:25
journal contribution
posted on 2023-06-12, 09:20 authored by Richard J Stevenson, Heather M Francis, Tuki Attuquayefio, Dolly Gupta, Martin YeomansMartin Yeomans, Megan J Oaten, Terry Davidson
Animals fed a Western-style diet (WS-diet) demonstrate rapid impairments in hippocampal function and poorer appetitive control. We examined if this also occurs in humans. One-hundred and ten healthy lean adults were randomised to either a 1-week WS-diet intervention or a habitual-diet control group. Measures of hippocampal dependent learning and memory (HDLM) and of appetitive control were obtained pre- and post-intervention. HDLM was retested at 3-weeks follow-up. Relative to controls, HDLM performance declined in the WS-diet group (d=0.43), but was not different at follow-up. Appetitive control also declined in the WS-diet group (d=0.47) and this was strongly correlated with HDLM decline (d=1.01). These findings demonstrate that a WS-diet can rapidly impair appetitive control in humans - an effect that could promote overeating in consumers of a WS-diet. The study also suggests a functional role for the hippocampus in appetitive control and provides new evidence for the adverse neurocognitive effects of a WS-diet.

History

Publication status

  • Published

File Version

  • Published version

Journal

Royal Society Open Science

ISSN

2054-5703

Publisher

Royal Society

Issue

2

Volume

7

Department affiliated with

  • Psychology Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2020-01-28

First Open Access (FOA) Date

2020-02-10

First Compliant Deposit (FCD) Date

2020-01-27

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