__smbhome.uscs.susx.ac.uk_tjk30_Documents_Mahoney_et_al-2015-Annals_of_Neurology.pdf (546.43 kB)
Longitudinal diffusion tensor imaging in frontotemporal dementia
journal contribution
posted on 2023-06-09, 20:22 authored by Colin J Mahoney, Ivor SimpsonIvor Simpson, Jennifer M Nicholas, Phillip D Fletcher, Laura E Downey, Hannah L Golden, Camilla N Clark, Nicole Schmitz, Jonathan D Rohrer, Jonathan M Schott, Hui Zhang, Sebastian Ourselin, Jason D Warren, Nick C FoxOBJECTIVE: Novel biomarkers for monitoring progression in neurodegenerative conditions are needed. Measurement of microstructural changes in white matter (WM) using diffusion tensor imaging (DTI) may be a useful outcome measure. Here we report trajectories of WM change using serial DTI in a cohort with behavioral variant frontotemporal dementia (bvFTD). METHODS: Twenty-three patients with bvFTD (12 having genetic mutations), and 18 age-matched control participants were assessed using DTI and neuropsychological batteries at baseline and ~1.3 years later. Baseline and follow-up DTI scans were registered using a groupwise approach. Annualized rates of change for DTI metrics, neuropsychological measures, and whole brain volume were calculated. DTI metric performances were compared, and sample sizes for potential clinical trials were calculated. RESULTS: In the bvFTD group as a whole, rates of change in fractional anisotropy (FA) and mean diffusivity (MD) within the right paracallosal cingulum were greatest (FA: -6.8%/yr, p < 0.001; MD: 2.9%/yr, p = 0.01). MAPT carriers had the greatest change within left uncinate fasciculus (FA: -7.9%/yr, p < 0.001; MD: 10.9%/yr, p < 0.001); sporadic bvFTD and C9ORF72 carriers had the greatest change within right paracallosal cingulum (sporadic bvFTD, FA: -6.7%/yr, p < 0.001; MD: 3.8%/yr, p = 0.001; C9ORF72, FA: -6.8%/yr, p = 0.004). Sample size estimates using FA change were substantially lower than neuropsychological or whole brain measures of change. INTERPRETATION: Serial DTI scans may be useful for measuring disease progression in bvFTD, with particular trajectories of WM damage emerging. Sample size calculations suggest that longitudinal DTI may be a useful biomarker in future clinical trials.
History
Publication status
- Published
File Version
- Published version
Journal
Annals of NeurologyISSN
1531-8249Publisher
WileyExternal DOI
Issue
1Volume
77Page range
33-46Pages
14.0Department affiliated with
- Informatics Publications
Research groups affiliated with
- Data Science Research Group Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-01-24First Open Access (FOA) Date
2020-01-24First Compliant Deposit (FCD) Date
2020-01-24Usage metrics
Categories
No categories selectedKeywords
AgedAnisotropyBrain/*pathologyCase-Control StudiesCognition Disorders/diagnosis/etiology*Diffusion Tensor ImagingDisease ProgressionFemaleFrontotemporal Dementia/complications/*diagnosis/geneticsHumansLongitudinal StudiesMaleMiddle AgedNeuropsychological TestsSensitivity and SpecificityWhite Matter/*pathology
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC