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The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain
Version 2 2023-06-12, 09:18
Version 1 2023-06-09, 20:13
journal contribution
posted on 2023-06-12, 09:18 authored by Dimple Karia, Robert C G Gilbert, Antonio J Biasutto, Catherine Porcher, Erika ManciniErika ManciniChromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in tightly regulated cell differentiation transcriptional programmes. However, the complex functional and physical interplay between transcription factors and chromatin modifying enzymes remains elusive. Recent evidence has implicated histone demethylases in normal haematopoietic differentiation as well as in malignant haematopoiesis. Here we report an interaction between H3K4 demethylase JARID1A and the haematopoietic-specific master transcription proteins SCL and GATA1 in red blood cells. Specifically, we observe a direct physical contact between GATA1 and the second PHD domain of JARID1A. This interaction has potential implications for normal and malignant haematopoiesis.
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Publication status
- Published
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- Published version
Journal
Royal Society Open ScienceISSN
2054-5703Publisher
Royal SocietyExternal DOI
Issue
1Volume
7Department affiliated with
- Biochemistry Publications
Research groups affiliated with
- Haematology Research Group Publications
Full text available
- No
Peer reviewed?
- Yes
Legacy Posted Date
2020-01-13First Open Access (FOA) Date
2020-01-13First Compliant Deposit (FCD) Date
2020-01-10Usage metrics
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