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The histone H3K4 demethylase JARID1A directly interacts with haematopoietic transcription factor GATA1 in erythroid cells through its second PHD domain

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Version 2 2023-06-12, 09:18
Version 1 2023-06-09, 20:13
journal contribution
posted on 2023-06-12, 09:18 authored by Dimple Karia, Robert C G Gilbert, Antonio J Biasutto, Catherine Porcher, Erika ManciniErika Mancini
Chromatin remodelling and transcription factors play important roles in lineage commitment and development through control of gene expression. Activation of selected lineage-specific genes and repression of alternative lineage-affiliated genes results in tightly regulated cell differentiation transcriptional programmes. However, the complex functional and physical interplay between transcription factors and chromatin modifying enzymes remains elusive. Recent evidence has implicated histone demethylases in normal haematopoietic differentiation as well as in malignant haematopoiesis. Here we report an interaction between H3K4 demethylase JARID1A and the haematopoietic-specific master transcription proteins SCL and GATA1 in red blood cells. Specifically, we observe a direct physical contact between GATA1 and the second PHD domain of JARID1A. This interaction has potential implications for normal and malignant haematopoiesis.

History

Publication status

  • Published

File Version

  • Published version

Journal

Royal Society Open Science

ISSN

2054-5703

Publisher

Royal Society

Issue

1

Volume

7

Department affiliated with

  • Biochemistry Publications

Research groups affiliated with

  • Haematology Research Group Publications

Full text available

  • No

Peer reviewed?

  • Yes

Legacy Posted Date

2020-01-13

First Open Access (FOA) Date

2020-01-13

First Compliant Deposit (FCD) Date

2020-01-10

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