UMN in ALS - J. Neurology, Neurosurgery & Psychiatry.pdf (439.76 kB)
Occasional essay: upper motor neuron syndrome in amyotrophic lateral sclerosis
journal contribution
posted on 2023-06-09, 20:11 authored by Michael Swash, David Burke, Martin R Turner, Julian Grosskreutz, Nigel LeighNigel Leigh, Mamede deCarvalho, Matthew C KiernanThe diagnosis of amyotrophic lateral sclerosis (ALS) requires recognition of both lower (LMN) and upper motor neuron (UMN) dysfunction.1 However, classical UMN signs are frequently difficult to identify in ALS.2 LMN involvement is sensitively detected by electromyography (EMG)3 but, as yet, there are no generally accepted markers for monitoring UMN abnormalities,4 the neurobiology of ALS itself, and disease spread through the brain and spinal cord,.5 Full clinical assessment is therefore necessary to exclude other diagnoses and to monitor disease progression. In part, this difficulty regarding detection of UMN involvement in ALS derives from the definition of ‘the UMN syndrome’. Abnormalities of motor control in ALS require reformulation within an expanded concept of the UMN, together with the neuropathological, neuro-imaging and neurophysiological abnormalities in ALS. We review these issues here.
History
Publication status
- Published
File Version
- Accepted version
Journal
Journal of Neurology, Neurosurgery and PsychiatryISSN
0022-3050Publisher
BMJ Publishing GroupExternal DOI
Issue
3Volume
91Page range
227-234Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-01-10First Open Access (FOA) Date
2020-01-10First Compliant Deposit (FCD) Date
2020-01-10Usage metrics
Categories
No categories selectedKeywords
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC