__smbhome.uscs.susx.ac.uk_tjk30_Documents_Accepted Lyzikova et al 2019.pdf (579.94 kB)
Increase in FoxP3, CD56 immune cells and decrease in glands PGRMC1 expression in the endometrium are associated with recurrent miscarriages
journal contribution
posted on 2023-06-09, 20:10 authored by Yulia Anatolievna Lyzikova, Dmitry Aleksandrovich Zinovkin, Md Zahidul Islam PranjolOBJECTIVE: Recurrent miscarriage (RM) is a multifactorial condition that involves frequent uterine anatomical abnormalities, parental karyotype abnormalities, and clotting disorders. We investigate the potential roles of endometrium FoxP3+ Tregs and CD56+ cells (uNK cells) and endometrial expression of PGRMC1 in the development of recurrent miscarriage. STUDY DESIGN: This prospective study included 102 out of 286 cases of SA patients. The cases were divided into groups with RM (+RM) and without RM (-RM). Immunohistochemistry staining was made using primary antibodies to FoxP3, CD56, and PGRMC1 in both groups. Morphometry analyses were carried out in 10 non-overlapping high power fields. Mann-Whitney U test, Fisher two-tail test, correlation analysis and relative risk (RR) were evaluated. A p?
History
Publication status
- Published
File Version
- Accepted version
Journal
European Journal of Obstetrics & Gynecology and Reproductive BiologyISSN
0301-2115Publisher
ElsevierExternal DOI
Volume
245Page range
121-126Department affiliated with
- Biochemistry Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2020-01-09First Open Access (FOA) Date
2020-01-09First Compliant Deposit (FCD) Date
2020-01-08Usage metrics
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