Antiretroviral blood levels in HIV/HCV-coinfected patients with cirrhosis after liver transplant: a report of three cases

Righi, E, Londero, A, Pea, F, Bonora, S, Nasta, P, Della Siega, P, Delle Foglie, P, Villa, G, Giglio, O, Dal Zoppo, S, Baccarani, U and Bassetti, M (2015) Antiretroviral blood levels in HIV/HCV-coinfected patients with cirrhosis after liver transplant: a report of three cases. Transplant Infectious Disease, 17 (1). pp. 147-153. ISSN 1398-2273

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Abstract

Since the introduction of combined antiretroviral therapy, human immunodeficiency virus (HIV) infection is no longer a contraindication for solid organ transplantation. In HIV/hepatitis C virus (HCV)‐coinfected patients undergoing liver transplantation, HCV‐related cirrhosis, drug‐drug interactions, and calcineurin inhibitors‐related toxicity affect clinical outcomes. Therapeutic drug monitoring can be useful to assess antiretroviral over‐ or underexposure in this cohort. We report the clinical characteristics along with antiretroviral trough levels of maraviroc, darunavir, and etravirine in 3 HIV/HCV‐coinfected liver transplant recipients who developed post‐transplant liver cirrhosis.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Brighton and Sussex Medical School > Global Health and Infection
Research Centres and Groups: Brighton and Sussex Centre for Global Health Research
Subjects: R Medicine
Depositing User: Deborah Miller
Date Deposited: 03 Jan 2020 15:17
Last Modified: 03 Jan 2020 15:17
URI: http://sro.sussex.ac.uk/id/eprint/89018

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