Intraperitoneal administration of Telmisartan prevents postsurgical adhesion band formation

Arjmand, Mohammad-Hassan, Zahedi-Avval, Farnaz, Barneh, Farnaz, Mousavi, Seyed Hadi, Asgharzadeh, Fereshteh, Hashemzehi, Milad, Soleimani, Atena, Avan, Amir, Fakhraie, Maryam, Nasiri, Seyedeh Najibeh, Mehraban, Saeedeh, Ferns, Gordon A, Ryzhikov, Mikhail, Jafari, Mohieddin, Khazaei, Majid and Hassanian, Seyed Mahdi (2020) Intraperitoneal administration of Telmisartan prevents postsurgical adhesion band formation. Journal of Surgical Research, 248. pp. 171-181. ISSN 0022-4804

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Abstract

Background
Angiotensin II receptor blockers (ARBs) have a potential role in reducing inflammation and fibrosis. We have integrated systems and molecular biology approaches to investigate the therapeutic potential of ARBs in preventing postsurgical adhesion band formation.

Material and methods
we have followed the ARRIVE guidelines point by point during experimental studies. Telmisartan (1 and 9 mg/kg), valsartan (1 and 9 mg/kg), and losartan (1 and 10 mg/kg) were administered intraperitoneally in different groups of male albino Wistar rat. After 7 d of treatment, macroscopic evidence and score of fibrotic bands based on scaling methods was performed. Moreover, the anti-inflammatory and antifibrosis effects of telmisartan on reduction of fibrotic bands were investigated by using histopathology, ELISA, and real-time polymerase chain reaction methods.

Results
Telmisartan, but not losartan or valsartan, prevented the frequency as well as the stability of adhesion bands. Telmisartan appears to elicit anti-inflammatory responses by attenuating submucosal edema, suppressing proinflammatory cytokines, decreasing proinflammatory cell infiltration, and inhibiting oxidative stress at the site of peritoneal surgery. We also showed that telmisartan prevents fibrotic adhesion band formation by reducing excessive collagen deposition and suppression of profibrotic genes expression at the peritoneum adhesion tissues.

Conclusions
These results support the potential application of telmisartan in preventing postsurgical adhesion band formation by inhibiting key pathologic responses of inflammation and fibrosis in postsurgery patients.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Brighton and Sussex Medical School
Subjects: R Medicine
Depositing User: Cherie Elody
Date Deposited: 11 Dec 2019 08:33
Last Modified: 31 Jan 2020 10:45
URI: http://sro.sussex.ac.uk/id/eprint/88704

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