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Intraperitoneal administration of Telmisartan prevents postsurgical adhesion band formation

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posted on 2023-06-09, 19:55 authored by Mohammad-Hassan Arjmand, Farnaz Zahedi-Avval, Farnaz Barneh, Seyed Hadi Mousavi, Fereshteh Asgharzadeh, Milad Hashemzehi, Atena Soleimani, Amir Avan, Maryam Fakhraie, Seyedeh Najibeh Nasiri, Saeedeh Mehraban, Gordon FernsGordon Ferns, Mikhail Ryzhikov, Mohieddin Jafari, Majid Khazaei, Seyed Mahdi Hassanian
Background Angiotensin II receptor blockers (ARBs) have a potential role in reducing inflammation and fibrosis. We have integrated systems and molecular biology approaches to investigate the therapeutic potential of ARBs in preventing postsurgical adhesion band formation. Material and methods we have followed the ARRIVE guidelines point by point during experimental studies. Telmisartan (1 and 9 mg/kg), valsartan (1 and 9 mg/kg), and losartan (1 and 10 mg/kg) were administered intraperitoneally in different groups of male albino Wistar rat. After 7 d of treatment, macroscopic evidence and score of fibrotic bands based on scaling methods was performed. Moreover, the anti-inflammatory and antifibrosis effects of telmisartan on reduction of fibrotic bands were investigated by using histopathology, ELISA, and real-time polymerase chain reaction methods. Results Telmisartan, but not losartan or valsartan, prevented the frequency as well as the stability of adhesion bands. Telmisartan appears to elicit anti-inflammatory responses by attenuating submucosal edema, suppressing proinflammatory cytokines, decreasing proinflammatory cell infiltration, and inhibiting oxidative stress at the site of peritoneal surgery. We also showed that telmisartan prevents fibrotic adhesion band formation by reducing excessive collagen deposition and suppression of profibrotic genes expression at the peritoneum adhesion tissues. Conclusions These results support the potential application of telmisartan in preventing postsurgical adhesion band formation by inhibiting key pathologic responses of inflammation and fibrosis in postsurgery patients.

History

Publication status

  • Published

File Version

  • Accepted version

Journal

Journal of Surgical Research

ISSN

0022-4804

Publisher

Elsevier

Volume

248

Page range

171-181

Department affiliated with

  • BSMS Publications

Full text available

  • Yes

Peer reviewed?

  • Yes

Legacy Posted Date

2019-12-11

First Open Access (FOA) Date

2021-01-14

First Compliant Deposit (FCD) Date

2020-01-03

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