Llorca, Alfredo, Ciceri, Gabriele, Beattie, Robert, Wong, Fong Kuan, Diana, Giovanni, Serafeimidou-Pouliou, Eleni, Fernández-Otero, Marian, Streicher, Carmen, Arnold, Sebastian J, Meyer, Martin, Hippenmeyer, Simon, Maravall, Miguel and Marin, Oscar (2019) A stochastic framework of neurogenesis underlies the assembly of neocortical cytoarchitecture. eLife, 8. pp. 1-78. ISSN 2050-084X

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Abstract

The cerebral cortex contains multiple areas with distinctive cytoarchitectonical patterns, but the cellular mechanisms underlying the emergence of this diversity remain unclear. Here, we have investigated the neuronal output of individual progenitor cells in the developing mouse neocortex using a combination of methods that together circumvent the biases and limitations of individual approaches. Our experimental results indicate that progenitor cells generate pyramidal cell lineages with a wide range of sizes and laminar configurations. Mathematical modelling indicates that these outcomes are compatible with a stochastic model of cortical neurogenesis in which progenitor cells undergo a series of probabilistic decisions that lead to the specification of very heterogeneous progenies. Our findings support a mechanism for cortical neurogenesis whose flexibility would make it capable to generate the diverse cytoarchitectures that characterize distinct neocortical areas.

Item Type:	Article
Schools and Departments:	School of Life Sciences > Neuroscience
Research Centres and Groups:	Sussex Neuroscience
Subjects:	Q Science > QP Physiology > QP0351 Neurophysiology and neuropsychology > QP0361 Nervous system
Depositing User:	Miguel Maravall
Date Deposited:	26 Nov 2019 10:34
Last Modified:	26 Nov 2019 10:45
URI:	http://sro.sussex.ac.uk/id/eprint/88282

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