Mapping the global distribution of podoconiosis: applying an evidence consensus approach

Deribe, Kebede, Simpson, Hope, Cano, Jorge, Pigott, David M, Davis Weaver, Nicole, Cromwell, Elizabeth A, Brady, Oliver J, Pullan, Rachel L, Noor, Abdisalan M, Argaw, Daniel, Murray, Christopher L J, Brooker, Simon J, Hay, Simon I, Newport, Melanie J and Davey, Gail (2019) Mapping the global distribution of podoconiosis: applying an evidence consensus approach. PLoS Neglected Tropical Diseases, 13 (12). a0007925. ISSN 1935-2727

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Background: Podoconiosis is a type of elephantiasis characterised by swelling of the lower legs. It is often confused with other causes of tropical lymphedema and its global distribution is uncertain. Here we synthesise the available information on the presence of podoconiosis to produce evidence consensus maps of its global geographical distribution.

Methods and findings: We systematically searched available data on podoconiosis in SCOPUS and MEDLINE from inception, updated to 10 May, 2019, and identified observational and population-based studies reporting podoconiosis. To establish existence of podoconiosis, we used the number of cases reported in studies and prevalence data with geographical locations. We then developed an index to assess evidence quality and reliability, assigning each country an evidence consensus score. Using these summary scores, we then developed a contemporary global map of national-level podoconiosis status.

There is evidence of podoconiosis in 17 countries (12 in Africa, three in Latin America, and two in Asia) and consensus on presence in six countries (all in Africa). We have identified countries where surveillance is required to further define the presence or absence of podoconiosis. We have highlighted areas where evidence is currently insufficient or conflicting, and from which more evidence is needed.

Conclusion: The global distribution of podoconiosis is not clearly known; the disease extent and limits provided here inform the best contemporary map of the distribution of podoconiosis globally from available data. These results help identify surveillance needs, direct future mapping activities, and inform prevention plans and burden estimation of podoconiosis.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Global Health and Infection
Research Centres and Groups: Brighton and Sussex Centre for Global Health Research
Subjects: R Medicine
Depositing User: Deborah Miller
Date Deposited: 20 Nov 2019 09:14
Last Modified: 18 Feb 2022 15:55

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Project NameSussex Project NumberFunderFunder Ref
The Global Atlas of PodoconiosisG1974WELLCOME TRUST201900/Z/16/Z