RUSTED_Aging_Neuropsychology_and_Cognition_SEP_2019_author_copy.pdf (587.2 kB)
Prospective memory: age related change is influenced by APOE genotype
journal contribution
posted on 2023-06-09, 19:26 authored by Claire LancasterClaire Lancaster, Mark A McDaniel, Naji TabetNaji Tabet, Jennifer RustedNon-focal prospective memory (PM) is sensitive to age-related decline; an additional impairment in focal PM is characteristic of mild stage Alzheimer’s disease. This research explored whether, by mid-adulthood, the distinct demands of focal and non-focal PM expose differences in carriers of an APOE e4 allele, a genetic risk factor for Alzheimer’s disease. Thirty-three young and 55 mid-age adults, differentiated by APOE genotype, completed a category-decision task with a concurrent focal or non-focal PM demand. Only mid-age e4 carriers showed a cost of carrying a focal PM intention. In addition, mid-age e4 carriers showed a significantly greater cost of carrying a non-focal PM intention than young e4 carriers, supporting a profile of accelerated aging. Consistency in the profile of cost differences observed in mid-age e4 carriers and pathological aging may indicate premature vulnerability. Future research correlating a shift in PM performance with early genotype differences in brain-based markers of decline is important.
History
Publication status
- Published
File Version
- Accepted version
Journal
Aging, Neuropsychology, and CognitionISSN
1382-5585Publisher
Taylor & FrancisExternal DOI
Issue
5Volume
27Page range
710-728Department affiliated with
- BSMS Neuroscience Publications
Full text available
- Yes
Peer reviewed?
- Yes
Legacy Posted Date
2019-10-28First Open Access (FOA) Date
2020-10-03First Compliant Deposit (FCD) Date
2019-10-21Usage metrics
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