Prospective memory: age related change is influenced by APOE genotype

Lancaster, Claire, McDaniel, Mark A, Tabet, Naji and Rusted, Jennifer (2020) Prospective memory: age related change is influenced by APOE genotype. Aging, Neuropsychology, and Cognition, 27 (5). pp. 710-728. ISSN 1382-5585

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Non-focal prospective memory (PM) is sensitive to age-related decline; an additional impairment in focal PM is characteristic of mild stage Alzheimer’s disease. This research explored whether, by mid-adulthood, the distinct demands of focal and non-focal PM expose differences in carriers of an APOE ε4 allele, a genetic risk factor for Alzheimer’s disease. Thirty-three young and 55 mid-age adults, differentiated by APOE genotype, completed a category-decision task with a concurrent focal or non-focal PM demand. Only mid-age ε4 carriers showed a cost of carrying a focal PM intention. In addition, mid-age ε4 carriers showed a significantly greater cost of carrying a non-focal PM intention than young ε4 carriers, supporting a profile of accelerated aging. Consistency in the profile of cost differences observed in mid-age ε4 carriers and pathological aging may indicate premature vulnerability. Future research correlating a shift in PM performance with early genotype differences in brain-based markers of decline is important.

Item Type: Article
Schools and Departments: Brighton and Sussex Medical School > Neuroscience
School of Psychology > Psychology
Depositing User: Sanjeedah Choudhury
Date Deposited: 28 Oct 2019 11:22
Last Modified: 03 Oct 2020 01:00

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